(A) Schematic diagram of the experimental system that detects calcium release from the endoplasmic reticulum by each ryanodine receptor. (B) Isoflurane selectively activates RyR1 (mean ± standard ...

Not many drugs are as widely used yet poorly understood as anesthetics. “We’ve used them for over a century, but nobody understands how they work,” says Alex Proekt, an anesthesiologist and ...